After obtaining the research ethics committee approval and the informed and written consent, patients of both genders, aged 21—56 years, physical status American Society of Anaesthesiologist ASA I and II who underwent lower limb orthopedic surgery, were enrolled into the present study. Although not orally active, DEX shows good bioavailability when administered via various other routes like intranasal, buccal, IM than intra-venous. Anesthesia induced with thiopentone sodium and intubation done with the help of succinylcholine and maintained with oxygen, nitrous oxide and isoflurane. However, in order to discover its full potential, indications, dosing and safety profile for various ages and procedures, it should urgently be examined by conducting good quality pediatric trials The purpose of this analysis was to test the stability of dexmedetomidine admixtures for 14 days.

An observational study carried out to evaluate the efficacy of dexmedetomidine sedation for awake craniotomy. We evaluated the feasibility of measuring memory and sedation responses in children during dexmedetomidine sedation for non-painful radiological imaging studies. The final pharmacokinetic parameter values were as follows: In addition, the airway, respiratory and cardiovascular complications along with postoperative nausea and vomiting, shivering, cough grading, Aldrete score, Ramsay sedation scale, and intraoperative awareness were recorded. Acta Vet Scand Suppl. Place and Duration of Study:

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All patients had smooth and rapid awakenings. More and more dental patients choose general anaesthesia for comfortable and painless surgery. Delayed awakening might be associated with this treatment. Results of clinical studies, decmedetomidine data of metanalyses, were discussed.

Implant surgery requires bone preparation, sometimes flap and bone graft treatment. All patients received 10 mg metoclopramide and The incidence of hypertension requiring treatment was significantly greater in the PLA group. Ketamine was administered with dexmedetomidine and opposed its bradycardiac effects. Intranasal dexmedetomidine is a feasible and safe acute treatment for adrenergic crisis in patients with familial dysautonomia. In this model of diet-induced obesity, a 1-hour propofol infusion.


Reversal by the alpha 2-adrenergic antagonist atipamezole. So It was beaten to death, combined with any and every LA through any and every route and in any and every surgery.

Mild, even severe pain following implant surgery is extremely to be expected [ 6 ].

Thirty-six evaluable infants, months old, postoperative from open heart surgery requiring mechanical ventilation. This was a retrospective cohort study of adult patients who received dexmedetomidine for ICU sedation while on mechanical ventilation at a bed not-for-profit community hospital.

Time to eye opening was prolonged in the dex group.

dexmedetomidine thesis topics

Just before the surgical procedure, all patients received IV propofol in a subhypnotic dose of 0. The average fentanyl consumption was Sixty patients enrolled in this project either have previously used DEX, midazolam, paracetamol, and other nonsteroidal anti-inflammatory drugs or had no known allergy to these drugs.

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Therefore, we conclude that dexmedetomidine infusion is an effective drug for preventing topiccs and providing sedation in patients during spinal anesthesia.

Transsphenoidal approach to pituitary tumors is a commonly performed procedure with the advantage of a rapid midline access to the sella with minimal complications.

Sixty patients undergoing septorhinoplasty were randomized into two groups.

dexmedetomidine thesis topics

Dexmedetomidine provides protections against toxic oxygen induced neonatal brain injury which is likely associated with oxidative stress signaling and inflammatory cytokines. Epidural analgesia offers superior pain relief and early mobilization especially when local anesthetic dose is combined with an adjuvant as compared to LA used thesks. Low dose ketamine decreases nociception by blocking NMDA receptor channels.

We surmised that DEX offered better postoperative analgesia by regulating the inflammatory and oxidation factors.

intraoperative dexmedetomidine infusion: Topics by

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The following parameters were observed dexmedetomudine after the administration of epidural block.

The comparison between groups was analyzed by the Mann-Whitney U test. We conducted a retrospective review of the DBS procedures that have been performed at our institution utilizing monitored anaesthesia care MAC via dexmedetomidine infusion to report on the frequency and type of perioperative complications as well as to assess the effectiveness of this technique.

Postoperative analgesia was prolonged significantly in the RD group Tracheal extubation is almost always associated with increase in sympathoadrenal activity may result in hypertension, tachycardia, and arrhythmias.

The mean heart rate was significantly lower in group D compared to groups E and N at all times of measurement P infusion of study drugs.

dexmedetomidine thesis topics

Despite its widespread use as a sedative and anesthetic adjunct, very few reports of dexmedetomidine -related polyuria in humans exist in the literature. Full Text Available Background: Post-operatively, the number of analgesic top-up doses of ropivacaine in group RD was significantly lower than the requirement for ropivacaine in group F.

Hemodynamic stability was one of the most remarkable fexmedetomidine observed with addition of dexmedetomidine and fentanyl to epidural ropivacaine.